@mac1
 

Discussion

[…] Because we did not collect participant samples prior to time point 1, it is not known how many of those participants had SARS-CoV-2 IgG antibodies prior to vaccination. In this cohort, there were too few individuals to determine whether there was a significant difference in average SARS-CoV-2 IgG antibody titers at any time point following both vaccination doses.

 

This study had several limitations. Due to our enrollment of health care workers, the average age of participants was low, with only 8 participants over the age of 50 years and only 1 participant over the age of 65 years. Participants were not monitored during specimen collection after the first time point, but the ability of participants to follow instructions for unobserved collection was validated internally prior to sample collection. All participants received the Moderna COVID-19 vaccine, and further research is needed to understand the longitudinal antibody response in oral or nasal mucosal fluid following other COVID-19 vaccines, such as the mRNA Pfizer/BioNtech vaccine and the viral vector Janssen vaccine. It is not yet known how oral mucosal fluid antibody titers are directly comparable to serum titers for the protection of infection or disease. […]

 

Quantification of SARS-CoV-2 IgG antibodies in oral fluid mucosal specimens of non-vaccinated individuals with previous SARS-CoV-2 infection demonstrated antibody persistence through 3.5 months without a significant decline. This may suggest persistence of SARS-CoV-2 IgG antibodies in oral mucosal fluid post-vaccination.

Detection of persistent SARS-CoV-2 IgG antibodies in oral mucosal fluid and upper respiratory tract specimens following COVID-19 mRNA vaccination