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Cardiac-related adverse events after BNT162b2 vaccination
Among various vaccines that are available, mRNA vaccines are the only ones approved for use in teenagers [
. Accessed Apr 2022" href="https://link.springer.com/article/10.1007/s00431-022-04786-0#ref-CR2">2
,
. Accessed Apr 2022" href="https://link.springer.com/article/10.1007/s00431-022-04786-0#ref-CR4">4
]. BNT162b2 has a better safety profile than mRNA-1273 Moderna, and is widely used for teenagers worldwide [5,
. Accessed Apr 2022" href="https://link.springer.com/article/10.1007/s00431-022-04786-0#ref-CR10">10
, 11].
However, cardiac-related adverse effects, as peri- and myocarditis, are
of particular concern because of possible serious complications [12].
In early June 2021, the US Food and Drug Administration issued a
warning about the rare adverse effect of myocarditis after being
administered mRNA COVID-19 vaccines [
. Accessed Apr 2022" href="https://link.springer.com/article/10.1007/s00431-022-04786-0#ref-CR13">13
].
In a report from the USA, the incidences of myocarditis were 70.7 and
105.8 cases per million in 12–15- and 16–17-year-old males receiving a
second dose of the BNT162b2 vaccine [14].
In a study in Israel, the incidence of myocarditis after a second dose
of BNT162b2 was 1.51 per 10,000 in 16–19-year-old males [15, 16].
In the present study, no clinical myocarditis was diagnosed and only
one case of subclinical mild myocarditis was found among 4928 students.
This result corresponds with previous findings that the incidence of
clinical and even subclinical myocarditis is very low in those receiving
a BNT162b2 vaccine.
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